PICO
Patient/Population
Children with severe therapy-resistant asthma (n=13)
Intervention
- Continuous Positive Airway Pressure (CPAP)
Comparison
- CPAP with minimum PEEP
Outcomes
- Exercise tolerance (PEF/FEV1/VO2)
Translatability (3/3) Easy
Comments: The results suggest that the use of CPAP before physical exercise increases exercise duration in children and adolescents with STRA. However, the IG (12.4 ± 2.1) presented a total test time (min) significantly (P = 0.01) longer than the CG (11.5 ± 1.3).
Limitations: Small sample size (n=13).
Appraisals:
PEDro Scale – (7/10) Blind subjects: No; Blind therapists: No. Intention-to-treat analysis: No (by PEDro – confirmed)
BTB
Intervention – 1
- CPAP (IG)
Dose
- PEEP at 10 cmH2O and FiO2 0.21, for 40 min.
Periodicity
- After a 15-day washout period, on a subsequent visit, subjects participated in the opposite group to the initial one.
Intervention – 2
- CPAP with minimum PEEP
Dose
- PEEP at 1 cmH20 for 40 min.
Periodicity
- After a 15-day washout period, on a subsequent visit, subjects participated in the opposite group to the initial one.
Citation:
Schindel, C. S., Schiwe, D., Heinzmann-Filho, J. P., Campos, N. E., Pitrez, P. M., & Donadio, M. (2021). Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma: a randomized crossover trial. World journal of pediatrics : WJP, 17(2), 189–196. https://doi.org/10.1007/s12519-021-00425-0