Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma: a randomized crossover trial (2021)

PICO

Patient/Population

Children with severe therapy-resistant asthma (n=13)

Intervention

  • Continuous Positive Airway Pressure (CPAP) 

Comparison

  •  CPAP with minimum PEEP

Outcomes

  • Exercise tolerance (PEF/FEV1/VO2)

Translatability   (3/3) Easy                                

Comments: The results suggest that the use of CPAP before physical exercise increases exercise duration in children and adolescents with STRA. However, the IG (12.4 ± 2.1) presented a total test time (min) significantly (P = 0.01) longer than the CG (11.5 ± 1.3).

Limitations: Small sample size (n=13).

Appraisals:

PEDro Scale  – (7/10) Blind subjects: No; Blind therapists: No. Intention-to-treat analysis: No (by PEDro – confirmed)

Metrics and
Journal Details:
scite_ report – 

 SCOPUS CiteScore View  / Resurchify Impact Score View 

BTB

Intervention – 1

  • CPAP (IG)

Dose

  • PEEP at 10 cmH2O and FiO2 0.21, for 40 min.

Periodicity

  • After a 15-day washout period, on a subsequent visit, subjects participated in the opposite group to the initial one.

Intervention – 2

  • CPAP with minimum PEEP

Dose

  • PEEP at 1 cmH20 for 40 min.

Periodicity

  • After a 15-day washout period, on a subsequent visit, subjects participated in the opposite group to the initial one.

Citation:
Schindel, C. S., Schiwe, D., Heinzmann-Filho, J. P., Campos, N. E., Pitrez, P. M., & Donadio, M. (2021). Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma: a randomized crossover trial. World journal of pediatrics : WJP, 17(2), 189–196. https://doi.org/10.1007/s12519-021-00425-0

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